THE CHOLINESTERASE INHIBITING ACTION OF FLUOROPHOSPHONATES
نویسندگان
چکیده
منابع مشابه
The inhibition of serum cholinesterase by alkyl fluorophosphonates.
During the war, a team of workers under Drs Saunders and McCombie prepared a series of fluorophosphonate esters and related compounds (McCombie & Saunders, 1946). Some of them were found to be highly toxic to animals by inhalation and very rapid in action, and to have a powerful myotic action when present in sub-lethal concentrations. In man, exposure to amounts of vapour insufficient to give a...
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A total of two new (1, 2) and four known (3-6) withanolides were isolated from the whole plant of Withania somnifera. Their structures were elucidated on the basis of spectroscopic techniques and were characterized as 6alpha,7alpha-epoxy-3beta,5alpha,20beta-trihydroxy-1-oxowitha-24-enolide (1), 5beta,6beta-epoxy-4beta,17alpha,27-trihydroxy-1-oxowitha-2,24-dienolide (2), withaferin-A (3), 2,3-di...
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Purified serum cholinesterase 90 mg was administered to a patient with cholinesterase deficiency. The effect on the action of suxamethonium was studied. The half-life (44.7 h), time constant (64.5 h), rate constant (0.0155 h-1) and distribution volume (2740 ml) of the cholinesterase activity were determined.
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From the leaves of Sarcococca coriacea two new steroidal alkaloids, epoxynepapakistamine-A [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-16alpha,17alpha-epoxy-2beta,4beta-di-O-acetate] (1), and epoxysarcovagenine-D [(20S)-20-(N-methylamino)-3beta-(tigloylamino)-5alpha-pregna-2-en-16alpha,17alpha-epoxy-4-one] (2), and two known compounds funtumafrine C [(20S)-20-(N,N-dimethylamino...
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We studied the effect of intravenous injection of the cholinesterase inhibitor galanthamine (GAL) in doses from 0.025 to 5.0 mg/kg on electrically evoked field potentials in rat visual cortex. In all the experiments the amplitude of late components of evoked potentials was significantly reduced, while early components remained unaffected. These findings indicate that cortical cells are inhibite...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1947
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1947.tb00320.x